Figure 6.

Chemogenetic inhibition of the CLA–PFC pathway attenuated methamphetamine-induced impulsivity. a, Experimental timeline of methamphetamine dose–response curve test (n = 10/group). b, METH did not affect accuracy. c, METH (1 mg/kg, i.p.) increased omissions. Inhibition of the CLA–PFC pathway had no effect on omissions. d, METH dose-dependently increased premature responses, which was attenuated by inhibition of the CLA–PFC pathway. e, Chemogenetic inhibition of the CLA–PFC pathway did not affect METH-induced hyperactivity (n = 6/group). Data were presented as mean ± SEM. *p < 0.05, #p < 0.05.