Figure 6.

EM of the Tfr^KO sciatic nerve. A, Electron micrographs of axons in the sciatic nerve of control and Tfr^KO mice at different postnatal time points. Scale bar, 6 μm. B, Mean g-ratio values of control and Tfr^KO mice at P15, P30, and P90. C, Mean diameter of myelinated axons in control and Tfr^KO mice. D, Area cover by bundles of unmyelinated axons. E, Percentage of myelinated axons of control and Tfr^KO animals. F, Scatter plot of g-ratio values of control and Tfr^KO mice at P15, P30, and P90. Lines indicate the regression equation with 95% CIs. P15 Control: r² = 0.0001; slope = 0.0004; 1/slope = −2474; F = 0.0118. P15 Tfr^KO: r² = 0.0001; slope = 0.0001; 1/slope = 5427; F = 0.0826. P30 Control: r² = 0.0034; slope = 0.0032; 1/slope = 306.4; F = 3.068. P30 Tfr^KO: r² = 0.0008; slope = 0.0017; 1/slope = −586.5; F = 0.5552. P90 Control: r² = 0.0091; slope = −0.0042; 1/slope = 237.0; F = 5.011. P90 Tfr^KO: r² = 0.0170; slope = 0.0055; 1/slope = 179.5; F = 10.72. Data are mean ± SEM. Six sciatic nerves per genotype and 200 fibers in each sciatic nerve were analyzed. **p < 0.01; ***p < 0.001; versus respective controls.