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. 2020 Jan 17;10:1544. doi: 10.3389/fphar.2019.01544

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Copyright © 2020 Fang, Li, Chen, Gao, Huang, Du, Jiang, Li and Ge

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of quercetin on the performance of lipopolysaccharide (LPS)-challenged rats in the saccharin preference test (SPT) and forced swimming test (FST). The data are presented as the mean ± SEM, with nine rats in each group. Compared with that in the control group, the sucrose preference index of rats in LPS-challenged group was lower (A) and the immobility time in the FST (B). These changes could be reversed by treatment with quercetin, fluoxetine, and ibuprofen. The immobility time in the FST was negatively correlated to the sucrose preference index (C) and the bodyweight gain (D). *P < 0.05, compared with the control group; ^# P < 0.05 and ^## P < 0.01, compared with the model group.