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. 2020 Jan 17;9:1547. doi: 10.3389/fonc.2019.01547

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Copyright © 2020 Yu, Zhang, Wei and Shao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) MGMT gene is located on chromosome 10, q26.3. (B) CpG island in MGMT. (B) In 1987, Gardiner-Garden and Frommer (1) identified the CpG island with 762 bp in MGMT gene. It has 98 CpG sites, located on about 480–1,480 nucleotide (nt) at the 5' end of this gene. The transcription start site (TSS) is located at nt956, CpG island covers a length of 500 bp at both 5' end and 3' end of TSS. The name of nt was first coined by Harris et al. (2), derived from the recognition site of restriction enzyme BamH1.