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E1A interferes with CBP/p300 in which regulate the transcription process of MGMT gene. CBP/p300 is a transcription coactivator and Sp1 is a transcription factor. CBP/p300 recruits Sp1 protein to recognize and bind to the GC region (5'-GGGCGG-3') in the MGMT promoter, which in turn acts as a transcriptional activator. On the other hand, E1A is a product of oncolytic adenovirus. It stops the Sp1 from being recruited by binding to p300. This blocks the MGMT gene transcription signal.
