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. 2020 Jan 17;7:385. doi: 10.3389/fcell.2019.00385

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Copyright © 2020 Tagliaferri, Mazzone, Noviello, Addeo, Angrisano, Del Vecchio, Visconte, Ruggieri, Russi, Caivano, Cantone, De Felice, Ceccarelli, Cerulo and Falco.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In silico analysis of Zscan4 regulatory network. (A) Blue and Yellow colors indicate positive vs negative regulation of Master Regulators (MRs). Overall were found 80 significant master regulators. The figure shows, for each significant master regulator, the distribution of regulons respect to RA-Zscan4⁺ vs. RA-Zscan4⁻ metastate phenotype. (B) The figure shows significant binding activity in the promoter region of Zscan4c.