Table 1.
Molecular characterization of antibiotic resistance mechanisms of 26 Ureaplasma spp. isolates
| Strain | Serovar | MICs (mg/liter)a | QRDRs analysisb | Macrolide resistance traitb | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OFX | CIP | LVX | MXF | AZM | ERY | JOS | ParC | ParE | L22 | ||
| ATCC 27815 | UPA3 | 0.25 (S) | 0.5 (S) | 0.125 (S) | 0.06 (S) | 0.06 (S) | 2 (S) | 0.03 (S) | WT | WT | WT |
| ATCC 27618 | UUR8 | 0.5 (S) | 0.5 (S) | 0.25 (S) | 0.06 (S) | 0.06 (S) | 2 (S) | 0.03 (S) | WT | WT | WT |
| U1 | UPA6 | 2 (MS) | 8 (R) | 1 (S) | 0.5 (S) | 1 (MS) | 64 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U2 | UPA1 | 2 (MS) | 4 (R) | 1 (S) | 0.5 (S) | 0.5 (MS) | 16 (R) | 0.5 (S) | WT | WT | A121S, T141I |
| U4 | UUR4, 10, 12, 13 | 2 (MS) | 4 (R) | 2 (S) | 0.5 (S) | 1 (MS) | 64 (R) | 0.03 (S) | WT | WT | A121S, T141I |
| U6 | UPA3 | 4 (R) | 4 (R) | 0.25 (S) | 0.5 (S) | 0.25 (MS) | 16 (R) | 0.125 (S) | WT | WT | A121S, T141I |
| U10 | UPA6 | 4 (R) | 8 (R) | 1 (S) | 0.5 (S) | 0.5 (MS) | 16 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U11 | UUR4, 10, 12, 13 | 4 (R) | 4 (R) | 4 (R) | 1 (S) | 1 (MS) | 32 (R) | 0.03 (S) | S83L | WT | A121S, T141I |
| U13 | UUR4, 10, 12, 13 | 4 (R) | 8 (R) | 4 (R) | 0.5 (S) | 0.25 (MS) | 64 (R) | 0.03 (S) | S83L | WT | A121S, T141I |
| U14 | UPA1 | 8 (R) | 16 (R) | 1 (S) | 0.5 (S) | 2 (MS) | 64 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U15 | UPA3 | 8 (R) | 8 (R) | 0.5 (S) | 0.5 (S) | 1 (MS) | 16 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U16 | UPA1 | 1 (S) | 4 (R) | 0.5 (S) | 0.25 (S) | 0.5 (MS) | 16 (R) | 0.125 (S) | WT | WT | A121S, T141I |
| U21 | UUR2, 5, 8, 9 | 8 (R) | 8 (R) | 4 (R) | 2 (S) | 1 (MS) | 64 (R) | 0.25 (S) | S83L | P446S | A121S, T141I |
| U22 | UUR2, 5, 8, 9 | 4 (R) | 4 (R) | 4 (R) | 1 (S) | 2 (MS) | 16 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U24 | UUR4, 10, 12, 13 | 4 (R) | 4 (R) | 4 (R) | 0.5 (S) | 1 (MS) | 64 (R) | 0.03 (S) | S83L | WT | A121S, T141I |
| U30 | UUR4, 10, 12, 13 | 4 (R) | 8 (R) | 4 (R) | 0.5 (S) | 1 (MS) | 32 (R) | 0.03 (S) | S83L | WT | A121S, T141I |
| U33 | UUR2, 5, 8, 9 | 4 (R) | 4 (R) | 4 (R) | 0.5 (S) | 1 (MS) | 64 (R) | 1 (S) | S83L | WT | A121S, T141I |
| U34 | UUR2, 5, 8, 9 | 4 (R) | 8 (R) | 4 (R) | 0.5 (S) | 0.5 (MS) | 16 (R) | 1 (S) | S83L | WT | A121S, T141I |
| U36 | UUR4, 10, 12, 13 | 4 (R) | 8 (R) | 4 (R) | 0.5 (S) | 0.25 (MS) | 64 (R) | 0.03 (S) | S83L | WT | A121S, T141I |
| U40 | UUR2, 5, 8, 9 | 4 (R) | 4 (R) | 4 (R) | 0.5 (S) | 0.5 (MS) | 64 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U47 | UUR4, 10, 12, 13 | 4 (R) | 4 (R) | 4 (R) | 1 (S) | 0.5 (MS) | 16 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U52 | UUR2, 5, 8, 9 | 4 (R) | 8 (R) | 4 (R) | 0.5 (S) | 1 (MS) | 64 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U54 | UUR4, 10, 12, 13 | 4 (R) | 8 (R) | 4 (R) | 1 (S) | 2 (MS) | 64 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U55 | UUR2, 5, 8, 9 | 8 (R) | 8 (R) | 4 (R) | 2 (S) | 2 (MS) | 64 (R) | 0.5 (S) | S83L | P446S | A121S, T141I |
| U56 | UUR4, 10, 12, 13 | 4 (R) | 4 (R) | 4 (R) | 1 (S) | 2 (MS) | 64 (R) | 0.25 (S) | S83L | WT | A121S, T141I |
| U66 | UUR4, 10, 12, 13 | 4 (R) | 4 (R) | 4 (R) | 1 (S) | 0.5 (MS) | 16 (R) | 0.5 (S) | S83L | WT | A121S, T141I |
| U67 | UUR4, 10, 12, 13 | 4 (R) | 4 (R) | 4 (R) | 1 (S) | 2 (MS) | 64 (R) | 0.25 (S) | S83L | WT | A121S, T141I |
| U84 | UUR2, 5, 8, 9 | 8 (R) | 8 (R) | 4 (R) | 2 (S) | 1 (MS) | 64 (R) | 0.5 (S) | S83L | P446S | A121S, T141I |
aS Sensitive, MS Moderately sensitive, R Resistant, bWT Wild-type