Table 2.
Fecal fatty acid concentrations and serum IS and pCS concentrations in healthy geriatric control cats, IRIS CKD stage 2 cats, and IRIS CKD stage 3 and 4 cats
| Healthy controls cats (n = 11) | CKD stage 2 (n = 16) | CKD stages 3 and 4 (n = 12) | |
|---|---|---|---|
| Variable | Median (range) | Median (range) | Median (range) |
| Fecal straight‐chain SCFA | |||
| Acetic (μmol/g) | 130 (28‐371) | 144 (31‐347) | 200 (43‐321) |
| Propionic (μmol/g) | 42 (11‐154) | 53 (8.1‐270) | 45 (11‐125) |
| Butyric (μmol/g) | 24 (7.0‐238) | 22 (4.9‐122) | 21 (2.3‐88) |
| Valeric (μmol/g) | 3.0 (0.4‐23) | 4.1 (0.2‐47) | 2.9 (0.4‐48) |
| Total SCFA (μmol/g) | 203 (48‐635) | 263 (50‐533) | 299 (59‐488) |
| Fecal BCFA | |||
| Isovaleric (μmol/g) | 4.3 (2.9‐7.4)a | 5.7 (3.1‐24) | 9.6 (2.5‐65)b |
| Isobutyric (μmol/g) | 3.4 (2.4‐6.6) | 4.4 (1.9‐17) | 6.4 (1.2‐26) |
| Total BCFA (μmol/g) | 7.8 (5.3‐14) | 10 (4.9‐40) | 15 (3.7‐91) |
| Serum gut‐derived uremic toxins | |||
| IS (ng/mL) | 1201 (202‐2860)a | 3200 (746‐10300)b | 5070 (1020‐27 600)b |
| pCS (ng/mL) | 2905 (901‐7220) | 7290 (34‐30 600) | 5890 (189‐35 300) |
Note: Rows with a different superscript letters are significantly different from one another.
Abbreviations: BCFA, branched‐chain fatty acid; IS, indoxyl sulfate; pCS, p‐cresol sulfate; SCFA, short‐chain fatty acid.