Table 6.

Clinical and renin‐angiotensin‐aldosterone data are presented for group 2 dogs in ACVIM heart disease stages C and D

Variable	ACVIM Stage C (n = 17) median (IQR)	ACVIM Stage D (n = 5) median (IQR)	P value	ACVIM Stage C mean (SD)	ACVIM Stage D mean (SD)
Age (years)	12.0 (10.4‐13.1)	11.1 (8.4‐11.8)	.2	11.9 (2.2)	10.4 (1.9)
Weight (kg)	6.62 (4.94‐15.30)	14.8 (7.29‐48.50)	.3
Furosemide dosage (mg/kg/day)	n = 16; 3.50 (2.46‐4.69)	n = 4; 7.69 (6.63‐14.54)	0.003
Torsemide dosage (mg/kg/day)	n = 1; 0.39	n = 1; 2.36	ND
Pimobendan dosage (mg/kg/day)	0.69 (0.55‐1.14)	2.03 (1.43‐3.73)	.002
ACE‐inhibitor dosage (mg/kg/day)	0.92 (0.76‐1.03)	1.01 (0.94‐1.63)	.01	0.91 (0.18)	1.23 (0.37)
Spironolactone dosage (mg/kg/day)	N = 15; 2.06 (1.64‐2.65)	N = 5; 2.14 (2.10‐4.37)	.3
Ang I (1‐10) (pM)	1628 (881‐2129)	2986 (1933‐5372)	.002	1414 (715)	3519 (2081)
Ang II (1‐8) (pM)	25.2 (14.85‐61.00)	19.20 (12.75‐26.2)	.3
Ang 1‐7 (pM)	359 (145‐555)	821 (286‐1210)	.01	356 (194)	763 (527)
Ang III (2‐8) (pM)	1.25 (1.25‐1.25)	1.25 (1.25‐1.25)	0.999
Ang 1‐5 (pM)	6.20 (1.45‐18.20)	7.00 (2.55‐42.5)	.4
Ang IV (3‐8) (pM)	3.2 (1.0‐5.4)	4.9 (1.0‐6.3)	.8
Aldosterone (pM)	50.9 (14.8‐295.6)	136.0 (39.3‐486.9)	.5
Ang I‐7/Ang II (1‐8)	13.5 (6.5‐16.7)	42.2 (15.8‐74.4)	.01
Ang I (1‐10) + Ang II (1‐8) (renin surrogate)	1640 (903‐2157)	2995 (1951‐5399)	.002	1459 (726)	3539 (2088)
Endogenous ACE activity [(pg Ang II/mL solvent)/hour]	2861 (2559‐3273)	1747 (1271‐2017)	.004	2937 (719)	1696 (424)

Notes: Data are reported as medians and interquartile ranges as well as means and standard deviations if normally distributed.

Abbreviations: ACE, angiotensin‐converting enzyme; ACVIM, American College of Veterinary Internal Medicine; Ang, angiotensin; IQR, interquartile range; ND, not done; SD, standard deviation.