Table 2.

Ability of different cutoff points of SDMA and serum creatinine to detect different categories of %GFR decrease below the mean GFR of the dog's body weight category

Variables	Sample size	Sensitivity %GFR ↓ ≥20% (95% CI)	Specificity %GFR ↓ ≥20% (95% CI)	Sensitivity %GFR ↓ ≥30% (95% CI)	Specificity %GFR ↓ ≥30% (95% CI)	Sensitivity %GFR ↓ ≥40% (95% CI)	Specificity %GFR ↓ ≥40% (95% CI)
SDMA > 10 μg/dL	90	96.8 (83.3‐99.9)	22.0 (12.3‐34.7)	94.7 (74.0‐99.9)	18.3 (10.1‐29.3)	90.9 (58.7‐99.8)	16.5 (9.1‐26.5)
SDMA > 12 μg/dL	90	83.9 (66.3‐94.6)	42.4 (29.6‐55.9)	88.9 (65.3‐98.6)	38.9 (27.6‐51.1)	90.0 (55.5‐99.8)	36.3 (25.8‐47.8)
SDMA > 14 μg/dL	90	74.2 (55.4‐88.1)	55.9 (42.4‐68.8)	72.2 (46.5‐90.3)	50.0 (38.0‐62.0)	90.0 (55.5‐99.8)	50.0 (38.6‐61.4)
SDMA > 16 μg/dL	90	62.5 (43.7‐78.9)	79.3 (66.7‐88.8)	66.7 (41.0‐86.7)	72.2 (60.4‐82.1)	90.0 (55.5‐99.8)	71.3 (60.1‐80.8)
SDMA > 18 μg/dL	90	45.2 (27.3‐64.0)	94.9 (85.9‐98.9)	55.6 (30.8‐78.5)	90.3 (81.0‐96.0)	80.0 (44.4‐97.5)	88.8 (79.7‐94.7)
SDMA > 20 μg/dL	90	29.0 (14.2‐48.0)	94.9 (85.9–98.9)	44.4 (21.5‐69.2)	94.4 (86.4‐98.5)	60.0 (26.2‐87.8)	92.5 (84.4‐97.2)
Creatinine ≥ 1.0 mg/dL	90	87.1 (70.2‐96.4)	52.5 (39.1‐65.7)	88.9 (65.3‐98.6)	45.8 (34.0‐58.0)	90.0 (55.5‐99.8)	42.5 (31.5‐54.1)
Creatinine ≥ 1.1 mg/dL	90	83.9 (66.3‐94.6)	67.8 (54.4‐79.4)	88.9 (65.3‐98.6)	59.7 (47.5‐71.1)	90.0 (55.5‐99.8)	55.0 (43.5‐66.2)
Creatinine ≥ 1.2 mg/dL	90	71.0 (52.0‐85.8)	81.4 (69.1‐90.3)	83.3 (58.6‐96.4)	75.0 (63.4‐84.5)	90.0 (55.5‐99.8)	70.0 (58.7‐79.7)
Creatinine ≥ 1.3 mg/dL	90	64.5 (45.4‐80.8)	88.1 (77.1‐95.1)	83.3 (58.6‐96.4)	83.3 (72.7‐91.1)	90.0 (55.5‐99.8)	77.5 (66.8‐86.1)
Creatinine ≥ 1.4 mg/dL	90	35.5 (19.2‐54.6)	96.6 (88.3‐99.6)	50.0 (26.0‐74.0)	94.4 (86.4‐98.5)	70.0 (34.8‐93.3)	92.5 (84.4‐97.2)
Creatinine ≥ 1.5 mg/dL	90	9.7 (2.0‐25.8)	100.0 (93.9‐100.0)	5.6 (0.1‐27.3)	97.2 (90.3‐99.7)	10.0 (0.3‐44.5)	97.5 (91.3‐99.7)

Abbreviations: GFR, glomerular filtration rate; SDMA, symmetric dimethylarginine.