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Tumor response to TME modification with a T cell activator. A dog with oral malignant melanoma (left panel) was treated with a series of every 2 week intratumoral injections of plasmid DNA encoding a bacterial superantigen gene (SEB), along with an IL-2 encoding plasmid. Tumor depigmentation was evident after the first injection (middle image) and complete tumor regression was noted after the second intratumoral injection (right panel).
