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. 2020 Jan 17;13:89. doi: 10.3389/fncom.2019.00089

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Copyright © 2020 Ibañez, Luebke, Chang, Draguljić and Weaver.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Perturbing the DRT young model cohort. Young cohort defined as networks from the LHS maintaining TPA-S when ν_ce = 5 Hz (679 networks, dark gray bar in Figure 3D, and bar for young simulations in all panels in this figure). For middle-aged and aged simulations: (A) Applied the synapse condition to young cohort, holding the excitability parameters constant. (B) Applied the excitability condition, holding synapse parameters constant. (C) Applied both observed data conditions simultaneously (excitability and synapse conditions). (D–F) Analogous perturbations as in (A–C), after adding synaptic facilitation to each network.