Table 3.
Univariate and Multivariable Analysis for Predictors of Inpatient Mortality Post–Clostridioides difficile Infection Diagnosis
| Houston Cohort | Validation Cohort | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariable Analysis | Univariate Analysis | Multivariable Analysis | |||||
| Covariate | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value |
| Eosinopenia + CDT | 10.8 (3.2–37.0) | <.001 | 7.8 (1.9–33.2) | .005 | 5.7 (1.8–17.8) | .003 | 6.1 (1.5–23.9) | .009 |
| Age, y | 1.02 (0.99–1.04) | .14 | 1.01 (0.99–1.03) | .19 | ||||
| CCI | 1.19 (1.02–1.39) | .02 | 1.23 (1.01–1.48) | .04 | 1.11 (1.04–1.19) | .002 | 1.09 (1.01–1.17) | .02 |
| SOT | 0.73 (0.17–3.14) | .67 | 9.0 (2.2–36.8) | .002 | ||||
| WBC, cells/μL | 1.05 (1.03–1.08) | <.001 | 1.03 (1.00–1.06) | .02 | 1.02 (1.01–1.04) | .005 | 1.01 (0.99–1.03) | .18 |
| SCr, mg/dL | 1.02 (0.88–1.19) | .76 | 0.96 (0.81–1.15) | .67 | ||||
| Albumin, g/dL | 0.15 (0.07–0.33) | <.001 | 0.18 (0.08–0.43) | <.001 | 0.48 (0.34–0.68) | <.001 | 0.53 (0.37–0.77) | <.001 |
| Severe CDI | 1.65 (0.75–3.64) | .21 | 17.4 (4.3–71.6) | <.001 | ||||
| HO-CDI | 2.95 (1.36–6.40) | .01 | 0.91 (0.57–1.47) | .71 | ||||
| History of CDIa | 0.49 (0.17–1.43) | .19 |
Abbreviations: CCI, Charlson Comorbidity Index; CDI, Clostridioides difficile infection; CDT, binary toxin; CI, confidence interval; HO-CDI, health care facility–onset CDI; OR, odds ratio; SCr, serum creatinine; SOT, solid organ transplantation; WBC, white blood cell count.
aNo patients with a history of CDI were included in the validation cohort.