Table 1.

The chemical components identified in the “Sanse powder” water extract

(A) positive ion mode
No.	Components	Chemical formula	ESI+, m/z	RT (min)	References
1	Arginine	C6H14N4O2	175.11895 [M+H]+, 116.70, 175.19, 71.84	0.63	[21]
2	Gentiopicroside	C16H20O9	357.11800	3.20	*
3	Ferulic acid	C10H10O4	195.06519 [M+H]+, 176.91, 137.88, 120.88	3.20	[21]
4	Strychnine	C21H22N2O2	335.1754 [M+H]+, 222.04, 234.09, 264.10	3.66	[22]
5	Brucine	C23H26N2O4	395.19653 [M+H]+ 324.11, 367.17, 350.18	3.99	[22]
6	Strychnine N-oxide	C21H22N2O3	351.17031 [M+H]+, 334.24, 306.16	4.33	[22]
7	Vomicine	C22H24N2O4	381.18088 [M+H]+, 324.14, 264.11, 306.17	5.06	[22]
8	Rutin	C27H30O16	611.16066 [M+H]+, 257.24, 285.20	6.13	[18]
9	Forsythoside A	C29H36O15	647.19464 [M+Na]+, 347.17, 321.13	6.46	[18]
10	Pinoresinol-β-d-glucoside	C26H32O11	543.18368 [M+Na]+, 218.93, 289.13	7.10	[18]
11	Phillyrin	C27H34O11	557.19933 [M+Na]+, 291.25, 218.96	10.38	[18]
12	Licorice-saponin G2	C42H62O17	839.40597 [M+H]+, 487.50, 627.38	16.92	[19]
13	Senkyunolides A	C12H16O2	193.1223 [M+H]+, 193.11, 174.95, 146.96	18.59	[23]
14	Imperatorin	C16H14O4	271.09648	21.80	*
15	Glycycoumarin	C21H20O6	369.13326 [M+H]+, 191.11, 285.09, 148.86	21.67	[19]
16	Curcymin	C21H20O6	369.13326	21.67	*
17	Ligustilide	C12H14O2	191.10665	21.82	*
18	3-Butylphthalide	C12H14O2	191.10665 [M+H]+, 191.07, 144.92, 172.92	21.82	[23]
19	Osthole	C15H16O3	245.11722	23.17	*
20	Cryptotanshinone	C19H20O3	297.14852 [M+H]+, 237.04, 251.65, 279.07	25.89	[20]
21	Tanshinone I	C18H12O3	277.08592	26.15	*
22	Senkyunolides P	C24H30O4	383.22168 [M+H]+, 383.32, 355.25, 365.20	29.75	[23]
23	Tanshinone II A	C19H18O3	295.13287 [M+H]+, 249.13, 277.11	30.06	[20]

(B) Negative ion mode
No.	Components	Chemical formula	ESI−, m/z	RT (min)	References
1	Loganic acid	C16H24O10	375.12857 [M−H]−, 213.06, 124.96, 112.86	1.25	[21]
2	Protocatechuic acid	C7H6O4	153.01824 [M−H]−, 81.08, 108.84	1.56	[24]
3	Chlorogenic acid	C16H18O9	353.08759 [M−H]−, 191.01, 173.93	2.44	[24]
4	Paeoniflorin	C23H28O11	479.15478	4.23	*
5	Isoorientin	C21H20O11	447.09219 [M−H]−, 327.04, 357.10, 429.20	4.76	[21]
6	Liquiritin apioside	C26H30O13	549.16026 [M−H]−, 417.22, 297.13, 255.15	6.11	[19]
7	Lithospermic acid	C27H22O12	537.10275 [M−H]−, 295.21, 493.21	7.46	[20]
8	Dicaffeoylquinic acid	C25H24O12	515.11840 [M−H]−, 190.93, 353.13	7.64	[23]
9	Rosmarinic acid	C18H16O8	359.07614 [M−H]−, 341.15, 160.93, 196.94, 179.02	8.56	[20]
10	Salvianolic acid B	C36H30O16	717.14260 [M−H]−, 519.22, 321.20	10.08	[20]
11	Quercetin	C15H10O7	301.03427	11.05	*
12	Oleanoic acid	C30H48O3	455.35197	35.31	*

* Compared with a standard. Other components were identified through comparison with m/z and mass fragmentation patterns reported in the literature