Table 3.

Standardised morbidity ratios (SMRs) comparing prevalence rates in adults with DS to UK population rates

	SMR males	SMR females
Autism	6.83 (6.04, 7.69)	17.60 (14.78, 20.67)
ADHD	5.04 (4.06, 6.27)	5.56 (4.50, 6.84)
Schizophrenia	3.67 (3.14, 4.27)	0.49 (0.33, 0.68)
Bipolar disorder	1.22 (1.05, 1.42)	0.79 (0.65, 0.95)
Depression	4.97 (4.66, 5.29)	3.97 (3.72, 4.23)
Anxiety	1.75 (1.61, 1.90)	0.57 (0.50, 0.64)
Dementia	43.33 (41.14, 45.58)	50.52 (48.13, 52.99)

Figures show SMRs (95% CI) adjusted for age and sex. Population rates for dementia were taken from Prince et al. [18], all other rates taken from McManus et al. [19]. If the CI for the SMR includes 1, there is no significant difference in rates for adults with DS and population rates. An SMR lower than 1 indicates the prevalence in adults with DS is lower than UK population rates. A value higher than 1 indicates the prevalence in adults with DS is higher than UK population rates. Non-overlapping CIs in SMRs for males and females indicate a significant sex difference relative to the population difference.

ADHD attention deficit hyperactivity disorder