Table 5.
Differentially regulated genes annotated to steroid biosynthesis in Du/CAF co-culture spheroids
| Symbol | Fold change | Name |
|---|---|---|
| AKR1C4 | 6.77 | Aldo-keto reductase family 1, member C4 |
| HSD11B2 | 5.37 | Hydroxysteroid (11-beta) dehydrogenase 2 |
| UGT1A1 | 5.22 | UDP glucuronosyltransferase 1 family, polypeptide A1 |
| AKR1C3 | 4.06 | Aldo-keto reductase family 1, member C3 |
| UGT1A3 | 3.04 | UDP glucuronosyltransferase 1 family, polypeptide A3 |
| DHCR7 | 2.31 | 7-dehydrocholesterol reductase |
| DHCR24 | 2.54 | 24-dehydrocholesterol reductase |
| LSS | 2.34 | Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) |
| HSD17B7 | 2.11 | Hydroxysteroid (17-beta) dehydrogenase 7 |
| SC4MOL | 2.41 | Sterol-C4-methyl oxidase-like |
| SC5DL | 2.60 | Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like |
| UGT2B11 | 2.31 | UDP glucuronosyltransferase 2 family, polypeptide B11 |
| CYP3A5 | 2.61 | Cytochrome P450, family 3, subfamily A, polypeptide 5 |
| HSD17B7 | 2.11 | Hydroxysteroid (17-beta) dehydrogenase 7 |
| UGT2B7 | 2.74 | UDP glucuronosyltransferase 2 family, polypeptide B7 |
| UGT2B10 | 2.57 | UDP glucuronosyltransferase 2 family, polypeptide B10 |
| UGT2B17 | 2.53 | UDP glucuronosyltransferase 2 family, polypeptide B17 |
| UGT1A6 | 0.42 | UDP glucuronosyltransferase 1 family, polypeptide A6 |