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. 2020 Jan 24;13:3. doi: 10.1186/s13072-020-0328-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — PHD domain array identifies 31 H3-interacting proteins. a PHD finger domain microarray probed with an unmodified H3 N-terminal peptide (1–20) (see “Methods”). Each positive binding interaction appears as a green circle, with each PHD protein in the array spotted in technical duplicate (indicated by connecting white lines). a PHD finger domain array probed with an H3 (1–20) peptide trimethylated at residue K4 (K4me3). c The 31 H3-interacting proteins are listed by their preference for binding H3 (1–20) K4me3 or K4me0. Each protein listed corresponds to the numbers in a, b. TTP Tandem Tudor domain + PHD, PPCC Dual PHD + Dual Chromodomain, PCC PHD + Dual Chromodomain, CW CW-type Zn-finger, PB PHD + Bromodomain, PPC2W2 Dual PHD + C2W2-type Zn-finger, SPB SAND + PHD + Bromodomain; domains not indicated, one PHD finger. For the entire list of proteins used and the microarray map, see Additional file 1: Table S1