Table 2.

The association between a burden of cerebral and arterial hyperoxia and the development of severe ROP (n = 8, total n = 225) as assessed by logistic regression analyses, unadjusted and adjusted for gestational age

	B	SE	OR (95% CI) per 10% burden increase	p value	aB	aSE	aOR (95% CI) per 10% burden increase	pa value
Burden of cerebral hyperoxia
80% rcSO2 threshold	0.190	0.136	1.21 (0.93–1.58)	0.160	−	−	−	−
85% rcSO 2 threshold	0.307	0.147	1.36 (1.02–1.81)	0.036*	0.404	0.162	1.50 (1.09–2.06)	0.013*
90% rcSO2 threshold	0.459	0.175	1.58 (1.12–2.23)	0.009*	0.594	0.197	1.81 (1.23–2.67)	0.003*
Burden of arterial hyperoxia
90% SaO2 threshold	−0.146	0.174	0.86 (0.62–1.21)	0.400	−0.018	0.199	0.98 (0.66–1.45)	0.928
92% SaO2 threshold	−0.118	0.144	0.89 (0.67–1.18)	0.412	−0.008	0.159	0.99 (0.72–1.36)	0.960
95% SaO2 threshold	−0.118	0.152	0.89 (0.66–1.20)	0.438	−0.012	0.164	0.98 (0.72–1.36)	0.940

Primary analyzed thresholds are bolded. aOR, adjusted odds ratio; aB, adjusted regression coefficient; aSE, adjusted standard error; B, regression coefficient; OR, odds ratio; p_a, adjusted p value; r_cSO₂, regional cerebral tissue oxygen saturation; ROP, retinopathy of prematurity; SaO₂, arterial oxygen saturation; SE, standard error.

^*Association between a hyperoxic burden and severe ROP at the 5% significance level.