Fig. 1.

Responder rates in patients with and without identified predictive criteria for response. Volume reduction criteria were “no airway disease,” low attenuation area ≥20%, residual volume (RV) ≥200% of predicted. Patients who met those criteria had significantly higher response rates in clinical endpoints, using standard minimum clinical important differences: RV −350 mL, forced expiratory volume in 1 s (FEV₁) 10%, 6-min walking test (6MWT) 26 m, St. George's Respiratory Questionnaire (SGRQ) −4 points. Both subgroups were treated in the most damaged lobes as measured by quantitative CT analysis. Reprinted from Slebos et al. [21] with permission of Elsevier.