Table 3.
Iron parameters and blood Hb concentration at baseline and at week 17 in DIALOGUE 2
| Parameter | Molidustat |
Darbepoetin |
||||||
|---|---|---|---|---|---|---|---|---|
| overall |
non-iron users |
overall |
on-iron users |
|||||
| baseline | week 17 | baseline | week 17 | baseline | week 17 | baseline | week 17 | |
| Hb, g/dL | 10.8±0.7 (92) 11.8±0.8 (75) | 10.8±0.7 (42) | 11.1±0.8 (32) | 10.9±0.7 (32) | 11.0±0.8 (27) | 10.8±0.9 (16) | 10.9±0.8 (12) | |
| Hepcidin, ng/mL | 37.6±28.9 (90) 29.4±23.2 (72) | 39.1±29.0 (40) | 24.9±21.8 (30) | 34.9±29.4 (31) | 48.8±40.6 (27) | 39.2±36.9 (15) | 51.1±41.2 (12) | |
| Ferritin, µg/L | 202.9±174.5 (92) 192.9±222.4 (70) | 201.8±145.7 (42) | 139.3±118.7 (30) | 249.3±270.0 (32) | 224.2±224.0 (27) | 301.6±241.1 (16) | 254.6±193.8 (12) | |
| Iron, µg/dL | 82.3±52.6 (91) 73.7±25.2 (70) | 88.7±68.7 (42) | 75.2±25.7 (30) | 77.8±27.2 (32) | 81.5±35.2 (27) | 83.2±26.7 (16) | 89.7±45.1 (12) | |
| TSAT, % | 31.8±13.0 (89) 29.8±9.3 (70) | 32.0±13.9 (40) | 30.1±12.2 (30) | 33.8±12.2 (31) | 34.0±10.9 (27) | 36.1±12.1 (15) | 35.8±11.1 (12) | |
| TIBC, µmol/L | 44.1±9.8 (91) 44.9±8.7 (70) | 44.2±8.4 (42) | 45.7±9.0 (30) | 42.7±8.4 (31) | 42.4±9.1 (27) | 44.0±9.4 (15) | 43.1±11.8 (12) | |
Data are mean ± SD (n).
Hb, hemoglobin; DIALOGUE, DaIly orAL treatment increasing endOGenoUs Erythropoietin; TSAT, transferrin saturation; TIBC, total iron binding capacity.