Table 4.
Iron parameters and blood Hb concentration at baseline and at week 17 in DIALOGUE 4
| Parameter | Molidustat |
Darbepoetin |
||||||
|---|---|---|---|---|---|---|---|---|
| overall |
non-iron users |
overall |
non-iron users |
|||||
| baseline | week 17 | baseline | week 17 | baseline | week 17 | baseline | week 17 | |
| Hb, g/dL | 10.5±0.6 (157) | 10.2±1.1 (105) | 10.5±0.6 (59) | 10.5±1.0 (39) | 10.6±0.5 (42) | 10.4±0.7 (39) | 10.6±0.6 (15) | 10.4±0.6 (13) |
| Hepcidin, ng/mL | 72.4±40.4 (156) | 73.0±49.6 (102) | 76.1±46.8 (59) | 62.0±43.1 (39) | 70.3±35.7 (42) | 75.6±48.8 (38) | 76.2±42.1 (15) | 80.6±49.0 (13) |
| Ferritin, µg/L | 556.5±315.0 (157) | 583.0±355.1 (102) | 559.9±357.9 (59) | 484.3±346.6 (38) | 542.1±331.4 (42) | 590.1±450.0 (39) | 528.1±319.7 (15) | 489.7±341.9 (13) |
| Iron, µg/dL | 67.8±25.0 (157) | 72.7±23.4 (102) | 69.4±29.5 (59) | 72.3±27.7 (38) | 63.6±21.4 (42) | 71.1 + 30.4 (39) | 63.3±20.3 (15) | 79.5±32.4 (13) |
| TSAT, % | 33.6±10.7 (157) | 34.8±11.8 (102) | 34.0±12.4 (59) | 33.1±12.5 (38) | 33.4±12.2 (42) | 34.0±11.4 (38) | 32.4±12.0 (15) | 36.2±12.5 (13) |
| TIBC, µmol/L | 36.1±5.6 (157) | 39.7±16.4 (102) | 36.3±5.5 (59) | 43.4±25.0 (38) | 35.0±6.6 (42) | 36.8±10.5 (39) | 36.1±7.1 (15) | 39.1±5.7 (13) |
Data are mean ± SD (n).
Hb, hemoglobin; DIALOGUE, DaIly orAL treatment increasing endOGenoUs Erythropoietin; TSAT, transferrin saturation; TIBC, total iron binding capacity.