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. 2020 Jan 23;9:F1000 Faculty Rev-37. [Version 1] doi: 10.12688/f1000research.21207.1

Figure 1. Schematic diagram of our Commentary on ‘Surface markers associated with chondrogenic potential of human mesenchymal stromal/stem cells’.

Figure 1.

Human mesenchymal stromal/stem cells (MSCs) were defined in 2006 by the International Society for Cellular Therapy. Unfortunately, currently accepted predictive surface markers do not seem to be ideal candidates to predict MSCs with chondrogenic potential in terms of inconsistency of currently accepted surface markers and chondrogenic potential of MSCs and tissue source–dependent MSC surface markers that correlate with chondrogenic potential. Are functionally predictive surface markers the next target for sorting MSCs in cartilage engineering and regeneration? ∝, positive correlation; ADSC, adipose-derived stromal/stem cell; BMSC, bone marrow-derived stromal/stem cell; dECM, decellularized extracellular matrix; FGF2, fibroblast growth factor 2; LTD EXP, limited expression; NR, not related; SDSC, synovium-derived stromal/stem cell.