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. 2020 Oct;59(10):1165–1177.e2. doi: 10.1016/j.jaac.2019.07.005

Table 3.

Borderline Symptoms (Measured on a Continuous Scale) of 12-Year-Olds Predict Poor Outcomes at Age 18

Age 18 outcome Model 1a Model 2b Model 3c
Personality β (95% CI) β (95% CI) β (95% CI)
 Openness to experience −.08 (−0.13, −0.03) −.02 (−0.08, 0.04) .00 (−0.10, 0.11)
 Conscientiousness −.16 (−0.21, −0.12) −.09 (−.14, −.03) .02 (−.11, .14)
 Extraversion .06 (0.02, 0.11) .13 (0.07, 0.18) .02 (−0.11, 0.14)
 Agreeableness −.28 (−0.32, −0.23) −.17 (−0.22, −0.11) −.08 (−0.17, 0.03)
 Neuroticism .23 (0.19, 0.28) .19 (0.13, 0.25) m.09 (−0.03, 0.22)
Poor mental health IRR (95% CI) IRR (95% CI) IRR (95% CI)
 Conduct disorder 1.41 (1.31, 1.51) 1.17 (1.05, 1.31) 1.02 (0.81, 1.29)
 Alcohol use disorder 1.12 (1.05, 1.19) 1.08 (0.99, 1.17) 0.99 (0.81, 1.22)
 Cannabis use disorder 1.44 (1.24, 1.66) 1.09 (0.89, 1.32) 1.04 (0.73, 1.49)
 Depression 1.18 (1.09, 1.28) 1.09 (0.99, 1.20) 0.95 (0.79, 1.15)
 Generalized anxiety disorder 1.13 (0.97, 1.31) 1.02 (0.83, 1.23) 1.32 (0.90, 1.92)
 Posttraumatic stress disorder 1.26 (1.05, 1.52) 1.15 (0.90, 1.47) 1.61 (0.86, 2.99)
 Suicide attempts or self-harm 1.38 (1.27, 1.50) 1.26 (1.13, 1.40) 1.10 (0.89, 1.35)
 Service use 1.31 (1.21, 1.41) 1.26 (1.14, 1.40) 1.18 (0.99, 1.40)
 Coinformant report of poor mental health 1.36 (1.29, 1.44) 1.21 (1.12, 1.31) 1.00 (0.87, 1.14)
Poor functioning IRR (95% CI) IRR (95% CI) IRR (95% CI)
 Low educational qualifications 1.40 (1.32, 1.49) 1.18 (1.08, 1.28) 1.13 (0.93, 1.38)
 NEET status 1.35 (1.21, 1.50) 0.99 (0.86, 1.13) 1.12 (0.74, 1.68)
 Cigarette smoking 1.40 (1.33, 1.49) 1.19 (1.09, 1.30) 1.00 (0.89, 1.11)
 Risky sexual behavior 1.29 (1.22, 1.37) 1.17 (1.07, 1.26) 0.93 (0.78, 1.11)
 Social isolation 1.23 (1.14, 1.33) 1.07 (0.97, 1.18) 1.14 (0.95, 1.37)
 Low life satisfaction 1.27 (1.17, 1.36) 1.06 (0.96, 1.17) 1.14 (0.95, 1.37)
 Official crime record 1.54 (1.40, 1.69) 1.19 (1.03, 1.36) 1.02 (0.84, 1.26)
Adolescent victimization IRR (95% CI) IRR (95% CI) IRR (95% CI)
 Maltreatment 1.89 (1.61, 2.22) 1.47 (1.09, 1.98) 1.18 (0.95, 1.46)
 Neglect 1.84 (1.56, 2.17) 1.63 (1.23, 2.16) 1.10 (0.61, 1.98)
 Sexual victimization 1.45 (1.22, 1.72) 1.00 (0.77, 1.29) 1.30 (0.80, 2.10)
 Family violence 1.30 (1.18, 1.44) 1.14 (1.00, 1.31) 0.85 (0.66, 1.11)
 Peer victimization 1.28 (1.17, 1.39) 1.17 (1.05, 1.31) 1.07 (0.87, 1.31)
 Cyber-victimization 1.32 (1.16, 1.50) 1.27 (1.07, 1.51) 1.15 (0.73, 1.80)
 Crime victimization 1.25 (1.16, 1.34) 1.16 (1.05, 1.29) 1.01 (0.84, 1.22)

Note: Boldface type indicates statistically significant estimates (p > .05). All outcome measures are described in Table 2. β = standardized regression coefficient; IRR = incidence rate ratio (interpretable as risk ratios); NEET = not in education, employment, or training.

a

Model 1: Analyses adjust for sex. For models additionally adjusting for baseline measures where possible, see Table S1, available online.

b

Model 2: Analyses additionally adjust for age 12 behavioral and emotional problems.

c

Model 3: Estimates are within-monozygotic-twin-pair estimates, ie, analyses adjust for the influence of genes and environments shared between genetically identical twins growing up in the same family.