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. Author manuscript; available in PMC: 2020 Jan 24.
Published in final edited form as: Neuropharmacology. 2017 Jun 3;123:126–135. doi: 10.1016/j.neuropharm.2017.06.002

Fig. 3. Flupirtine, unlike phenobarbital, very effectively reduces seizure activity during the immediate reperfusion period.

Fig. 3.

A single dose of flupirtine administered during the immediate reperfusion period (5 min after the rat is reintroduced to the room air after a 2 h hypoxia period) reduced (A) the percent of rats developing electroclinical seizures and (B) the number and (C) total duration of electroclinical seizures during the reperfusion period. The data shown in the B and C histograms are mean ± SD. *, **Statistically different from HI + V group; *p < 0.05, **p < 0.01, Fisher’s exact test was used to compare data in A, and One-way ANOVA and Tukey’s post-hoc test was used to compare data in B and C. ECS = electroclinical seizure, HI = hypoxia-ischemia, V = vehicle, F = flupirtine, P = phenobarbital.