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. Author manuscript; available in PMC: 2020 Mar 11.
Published in final edited form as: Nature. 2019 Sep 11;573(7775):590–594. doi: 10.1038/s41586-019-1551-2

Extended Data Fig. 10 |. Effects of the loss of G3BP1 on NLRP3 inflammasome activation and intraperitoneal injection of arsenite on the release of inflammatory cytokines.

Extended Data Fig. 10 |

a, Immunoblot analysis of CASP1 cleavage, total G3BP1 and GAPDH in wild-type and dCas9-expressing immortalized BMDMs transduced with two different gRNAs that target G3bp1. Representative blots (n = 3). b, c, Quantification of inflammatory cytokines in an LPS-induced peritonitis model with or without intraperitoneal injection of arsenite, in serum (b) and in peritoneal fluid (c). P values: **P = 0.0051 (IP-10 in serum), **P = 0.0024 (RANTES in peritoneal fluid) by unpaired two-sided t-test. Data are mean ± s.e.m. (n ≥ 6).