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Schematic representation of improved oxcarbazepine (OXC) penetration across the blood–brain barrier (BBB). The nonsilenced or noninhibited epileptic brain endothelial cells (EPI-EC) demonstrated increased drug metabolic potency at the BBB. Conversely, silencing the GR in EPI-ECs resulted in a reduction of OXC metabolism compared with nonsilenced conditions in EPI-ECs. In this manner, the penetration of OXC across the BBB EPI-ECs was improved upon GR silencing or inhibition [59].
