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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Drug Discov Today. 2019 Sep 18;25(1):89–106. doi: 10.1016/j.drudis.2019.09.009

FIGURE 4.

FIGURE 4

Regional glucocorticoid receptor (GR) dysregulation in brain regions. Dysregulation or abnormal expression of the GR, as well as associated hypothalamic-pituitary-adrenal axis abnormalities, can cause disease pathogenesis in the brain. However, certain diseases are associated with GR dysregulation localized to specific regions of the brain. Green boxes indicate the role of the GR in normal conditions. Red boxes indicate abnormal GR expression, activity or response to pathophysiological conditions.