Table III.
COX-2 genotypes and the risk of advanced colorectal adenoma.
| Genotype | Cases/controls | OR | 95% CI | P-value |
|---|---|---|---|---|
| 466 rs689462 | ||||
| AA | 45/79 | 1.00 | - | - |
| AC | 20/40 | 1.00 | 0.51–1.93 | 0.99 |
| CC | 4/14 | 0.61 | 0.18–2.03 | 0.42 |
| 663 rs689464 | ||||
| GT | 39/72 | 1.00 | - | - |
| GT/del | 26/45 | 1.09 | 0.58–2.05 | 0.80 |
| del | 2/14 | 0.29 | 0.06–1.38 | 0.12 |
| 861 rs20415 | ||||
| GG | 60/111 | 1.00 | - | - |
| AG | 9/21 | 0.80 | 0.34–1.88 | 0.61 |
| AA | 3/17 | 0.29 | 0.08–1.04 | 0.06 |
| 2331 rs2745557 | ||||
| CC | 51/93 | 1.00 | - | - |
| CT | 18/31 | 1.10 | 0.55–2.20 | 0.78 |
| TT | 0/18 | - | - | - |
| 5072 rs4648274 | ||||
| AA | 53/97 | 1.00 | - | - |
| AC | 15/29 | 0.99 | 0.48–2.05 | 0.98 |
| CC | 1/5 | 0.38 | 0.04–3.34 | 0.38 |
| 5229 rs20432 | ||||
| TT | 16/21 | 1.00 | - | - |
| TG | 32/90 | 0.42 | 0.19–0.92 | 0.03 |
| GG | 25/34 | 1.05 | 0.44–2.50 | 0.91 |
| 5625 rs2066826 | ||||
| GG | 31/56 | 1.00 | - | - |
| AG | 27/57 | 0.82 | 0.43–1.57 | 0.61 |
| AA | 12/16 | 1.38 | 0.57–3.36 | 0.49 |
| 6064 rs4648276 | ||||
| TT | 55/94 | 1.00 | - | - |
| CT | 14/32 | 0.70 | 0.34–1.45 | 0.34 |
| CC | 1/4 | 0.42 | 0.04–4.09 | 0.45 |
| 8344 rs4648291 | ||||
| TTATA | 26/54 | 1.00 | - | - |
| TTATA/del | 29/54 | 1.06 | 0.54–2.07 | 0.86 |
| del | 15/23 | 1.54 | 0.68–3.56 | 0.31 |
| 8494 rs5275 | ||||
| CC | 23/52 | 1.00 | - | - |
| CT | 31/58 | 1.20 | 0.61–2.34 | 0.60 |
| TT | 16/26 | 1.53 | 0.68–3.45 | 0.30 |
| 10494 rs689470 | ||||
| TT | 12/18 | 1.00 | - | - |
| CT | 26/61 | 0.54 | 0.22–1.32 | 0.18 |
| CC | 32/53 | 0.86 | 0.36–2.06 | 0.74 |
| 10848 rs4648306 | ||||
| GG | 55/95 | 1.00 | - | - |
| AG | 14/30 | 0.77 | 0.37–1.61 | 0.49 |
| AA | 1/5 | 0.32 | 0.04–2.94 | 0.31 |
| 10935 rs4648308 | ||||
| GG | 23/38 | 1.00 | - | - |
| AG | 22/66 | 0.39 | 0.18–0.83 | 0.01 |
| GG | 24/38 | 0.85 | 0.39–1.84 | 0.68 |
Ancestral alleles are treated as wild-type. OR, odds ratio; CI, confidence interval. Values are adjusted for gender and smoking.