. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Ann Neurol. 2019 Dec 5;87(2):267–280. doi: 10.1002/ana.25649

TABLE 1.

Demographic Information

Characteristic	CN		MCI		Dementia		All
Characteristic	Low Aβ	High Aβ	Low Aβ	High Aβ	Low Aβ	High Aβ	All
Subjects, n	239	121	244	352	17	97	1,070
APOEε4⁺, n (% of subsample)	46 (19.3)	52 (43.0)^a	56 (23.0)	236 (67.1)^a	0 (0.0)^a	73 (75.3)^a	463 (43.2)
Female sex, n (% of subsample)	112 (46.9)	77 (63.6)^b	106 (43.4)	150 (42.6)	2 (11.8)^b	45 (46.4)	492 (46.0)
Progression to MCI, n	32	36	—	—	—	—	68
Progression to dementia, n	2	4	14	121	—	—	141
Baseline age, yr, mean (SD)	74.1 (6.7)	76.5 (6.3)^a	71.3 (8.3)^a	74.1 (7.2)	79.9 (6.3)^a	74.9 (8.3)	73.9 (7.5)
Education, yr, mean (SD)	16.7 (2.5)	16.0 (2.8)^b	16.4 (2.5)	16.1 (2.8)^b	16.2 (2.1)	15.2 (2.8)^a	16.2 (2.7)
Baseline MMSE, mean (SD)	29.1 (1.2)	28.9 (1.2)	28.1 (2.7)^a	26.8 (2.9)^a	21.6 (6.4)^a	22.4 (2.7)^a	27.4 (3.2)
Baseline logical memory, mean (SD)	15.4 (4.0)	14.9 (4.1)	9.2 (5.0)^a	11.4 (5.5)^a	5.7 (5.5)^a	4.9 (3.6)^a	11.3 (5.9)
Baseline ECog memory score: participant, mean (SD)	1.7 (0.5)	1.7 (0.5)	2.2 (0.7)^a	2.4 (0.7)^a	2.1 (0.7)^a	2.3 (0.8)^a	2.1 (0.7)
Baseline ECog memory score: partner, mean (SD)	1.4 (0.5)	1.4 (0.4)	2.0 (0.7)^a	2.5 (0.8)^a	3.3 (0.5)^a	3.5 (0.5)^a	2.1 (0.9)
Baseline awareness index, mean (SD)	0.3 (0.6)	0.3 (0.5)	0.3 (0.9)	−0.1 (0.9)^a	−1.1 (1.0)^a	−1.2 (1.0)^a	−0.0006 (0.9)
ECog follow-up duration, yr, mean (SD)	3.1 (1.4)	3.0 (1.5)	3.4 (1.6)^b	2.8 (1.6)^b	1.7 (1.6)^a	1.1 (1.0)^a	2.9 (1.6)
Number of ECog visits, mean (SD)	4.1 (1.2)	4.0 (1.3)	5.0 (1.7)^a	4.5 (1.6)^b	3.1 (1.6)^b	2.6 (1.0)^a	4.3 (1.6)

Subject information is presented across 6 levels of baseline diagnosis and baseline Aβ as well as the full sample (N = 1,070). Missing data: 5 participants did not have information regarding biological sex, 7 did not have APOEε4 status, and 5 did not have information regarding years of education.

Significantly different from CN, low amyloid (p < 0.001).

Significantly different from CN, low amyloid (p < 0.05).

APOEε4 = apolipoprotein E4 genotype; Aβ = beta-amyloid; CN = clinically normal; ECog = Everyday Cognition scale; MCI = mild cognitive impairment; MMSE = Mini-Mental State Examination; SD = standard deviation.