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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Ann Neurol. 2019 Dec 5;87(2):267–280. doi: 10.1002/ana.25649

TABLE 6.

Floodlight and Spotlight Analyses for Diagnostic Progression

Estimate SE df t P
CN to MCI, n = 68
 Intercept, 4 years before MCI 0.36 0.09 295 3.77 <0.001a
 Intercept, 3 years before MCI 0.28 0.08 295 3.40 <0.001a
 Intercept, 2 years before MCI 0.20 0.08 295 2.64 0.009b
 Intercept, 1 years before MCI 0.12 0.08 295 1.56 0.12
 Intercept, at the time of MCI 0.04 0.09 295 0.47 0.64
 Time −0.08 0.03 295 3.12 0.002b
MCI to dementia, n = 135
 Intercept, 4 years before dementia −0.03 0.12 592 −0.23 0.82
 Intercept, 3 years before dementia −0.26 0.10 592 2.67 0.007b
 Intercept, 2 years before dementia −0.49 0.07 592 −6.48 <0.001a
 Intercept, 1 years before dementia −0.71 0.06 592 −11.3 <0.001a
 Intercept, at the time of dementia −0.94 0.06 592 −14. 72 <0.001a
 Time −0.23 0.03 592 −7.68 <0.001a
a

p < 0.001.

b

p < 0.05.

CN = clinically normal; MCI = mild cognitive impairment; SE = standard error.