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. Author manuscript; available in PMC: 2020 Jan 24.
Published in final edited form as: J Med Chem. 2019 Aug 9;62(16):7489–7505. doi: 10.1021/acs.jmedchem.9b00625

Figure 4.

Figure 4.

Alignment of the P. aeruginosa BC enzyme (shown in yellow ribbon; PBD 2VQD) co-crystallized with substrate analog AMPCP (carbon, yellow; nitrogen, blue; phosphate, orange; oxygen, red; all rendered as sticks) and the H. influenzae BC enzyme (shown in light blue ribbon) co-crystallized with 14a (carbon, light blue; nitrogen, blue; chlorine, light green; all rendered as sticks; PDB code 6OI8). Resistance-conferring mutants were found at residue positions 278 and 437, which in the WT enzymes shown here are leucine and isoleucine, respectively (shown as sticks).