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(A) Effect of compound 9 on capsaicin-induced hypothermia in mice (B) analgesic activity of compound 9 on CCI-induced cold allodynia after oral administration in mouse
| (A) CAP-induced hypothermia | ||||
|---|---|---|---|---|
| Dose (mpk) | 0.1 | 0.3 | 1 | 10 |
| Inhibition % | 25 | 38 | 60 | 91 |
| (B) CCI model | ||||
| Dose (mpk) | 0.0001 | 0.001 | 0.01 | 0.1 |
| MPE | 21.9 (±4.2) | 30.5 (±5.9) | 52.9 (±5.6) | 47.1 (±8.0) |
Data, n = 10, mean±SEM, *p <0.05 versus vehicle. MPE, maximal possible effect. mpk, mg per Kg.
