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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Nat Rev Endocrinol. 2019 Dec 2;16(2):91–103. doi: 10.1038/s41574-019-0282-7

Fig. 2 |. Integrating multi-omics data to elucidate the molecular mechanisms of osteoporosis.

Fig. 2 |

Multiple omics technologies, including genomics (mainly refers to genome-wide association studies (GWAS)), transcriptomics, epigenomics, proteomics and metabolomics, have been applied to dissect the pathogenesis of osteoporosis. Each technology individually can only provide limited insights into the biological mechanisms of osteoporosis. By integrating multiple omics data and following-up functional experiments in cell lines and/or animal models, researchers could capture a comprehensive view of the pathogenesis of this disorder.