Table 3.

Studies of other somatic gene mutations in patients who underwent resection of colorectal liver metastases

Gene analyzed	Reference	Year	No. of patients	Frequency	Multivariable analysis	Association of gene mutation with prognosis
						OS	RFS
TP53	Tullo et al. [34]	1999	40	19 (48%)	No	-	Worse
	Yang et al. [35]	2001	39	16 (41%)	No	Better	Better
	Saw et al. [39]	2002	60	35 (58%)	No	No association	-
	De Jong et al[40]	2005	44	16 (36%)	No	No association	No association
	Mollevi et al. [36]	2007	91	46 (51%)	Yes	Worse	-
	Pilat et al. [38]	2015	76	42 (55%)	No	Worse*	-
	Loes et al. [25]	2016	164	99 (60%)	Yes	No association	No association
	Fankel et al. [41]	2017	165	95 (58%)	No	No association	-
	Chun et al. [42]	2019	401	263 (66%)	No	No association	-
	Kawaguchi et al. [15]	2019	507	359 (71%)	Yes	Worse	Worse
PIK3CA	Loes et al. [25]	2016	164	22 (13%)	Yes	No association	No association
	Fankel et al. [41]	2017	165	20 (12%)	No	No association	No association
	Kawaguchi et al. [15]	2019	507	80 (16%)	Yes	No association	No association
SMAD4	Mizuno et al. [47]	2018	278	37 (13%)	Yes	Worse	-
	Kawaguchi et al. [15]	2019	507	56 (11%)	Yes	Worse	Worse

Abbreviations: OS, overall survival; RFS, recurrence-free survival.

^*51 patients who received preoperative chemotherapy