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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Mol Neurobiol. 2019 Sep 6;57(1):1–10. doi: 10.1007/s12035-019-01751-1

Fig. 1. Sevoflurane exposure dysregulates neonatal cortical NKCC1 and KCC2.

Fig. 1

Immediately after 6 hours exposure to sevoflurane, cortical NKCC1 increased over two-fold compared to controls, p = .03 (a), but KCC2 was not affected, p = .30 (b). Upregulation of NKCC1 resulted in increased NKCC1/KCC2 ratio, p =.02 (c). Twenty-four hours after initial exposure, we observed no differences in NKCC1 protein expression between control and sevoflurane pups, p =.84 (d). However, at this time point, KCC2 was significantly reduced, p = .009 (e), leading to increased NKCC1/KCC2 ratio, p = .03 (f). Boxed numbers in bars represent n per group