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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Mol Neurobiol. 2019 Sep 7;57(1):41–50. doi: 10.1007/s12035-019-01755-x

Figure 2. Open-field behavior of rats exposed to general anesthesia at P7.

Figure 2.

A-B. Total distance traveled in the open-field arena during 10 min, measured in adolescent (A) and young adult rats (B). Female rats traveled longer distances than male littermates at both time points, as assessed by two-way ANOVA (adolescent – factor sex: F1,79=20.58, p<0.001; young adult – factor sex: F1,79=39.58, p<0.001; interaction and factor treatment not significant for both age groups). The number of animals in each group is indicated at the bottom of each bar. C-D. The distance traveled in the border zone (36% of the entire arena), measured in adolescent (C) and young adult rats (D). Female rats traveled longer distances in the border zone than male littermates at both time points (adolescent – factor sex: F1,79=8.49, p=0.005; young adult – factor sex: F1,79=6.03, p=0.016; interaction and factor treatment not significant for both age groups). E-F. The number of entries to the inner zone, measured in adolescent (E) and young adult rats (F). Both male and female young adult rats exposed to GA at P7 had more entries to the inner zone of the open-field arena (64% of the entire arena), as compared to the Sham group (factor treatment: F1,79=6.58, p=0.012; interaction not significant). Female rats had overall fewer entries to the inner zone (factor sex: F1,79=9.88, p=0.002). *p<0.05, **p<0.01 and ***p<0.001, two-way ANOVA. Each bar represents the mean + SEM.