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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Mol Neurobiol. 2019 Sep 7;57(1):41–50. doi: 10.1007/s12035-019-01755-x

Figure 3. Anxiety-related behavior of Sham and GA-exposed rats in the elevated plus-maze.

Figure 3.

A. Total distance traveled in the elevated plus-maze during 5 min, measured in young adult rats. Female rats, irrespective of treatment, traveled longer distances than male littermates at both time points, as assessed by two-way ANOVA (factor sex: F1,79=73.50, p<0.001; interaction and factor treatment not significant). The number of animals in each group is indicated at the bottom of each bar. B. The percent of time young adult rats spent in open arms of the elevated plus-maze. Female rats, regardless of treatment, showed lower anxiety than male littermates (factor sex: F1,79=81.44, p<0.001; interaction and factor treatment not significant). C. The distance traveled in the distal zone of the open arms measured in young adult rats. Female rats, regardless of treatment, had longer distances in the distal parts of the open arms than male littermates (factor sex: F1,79=98.35, p<0.001; interaction not significant). Both male and female young adult rats exposed to GA at P7 traveled shorter distances in the distal zone, relative to Sham controls (factor treatment: F1,79=4.46, p=0.038). D. The number of entries to the distal zone of the open arms, measured in young adult rats. Female rats, regardless of treatment, explored the distal parts of the open arms more freely than male littermates (factor sex: F1,79=108.00, p<0.001; interaction not significant). Both male and female young adult rats exposed to GA at P7 had fewer entries to the distal zone than Sham controls (factor treatment: F1,79=4.92, p=0.030). *p<0.05 and ***p<0.001, two-way ANOVA. Each bar represents the mean + SEM.