Table 1. Bidirectional MR estimates for the association between chronic periodontitis and Alzheimer’s disease.
Method | Periodontitis on Alzheimer’s disease | Alzheimer’s disease† on periodontitis | |||||||
---|---|---|---|---|---|---|---|---|---|
Instrumental SNPs* from Munz et al. | Instrumental SNPs# from Shungin et al. | ||||||||
OR (95% CI) | P value | Q statistic/ P value |
OR (95% CI) | P value | Q statistic/ P value |
OR (95% CI) | P value | Q statistic/ P value |
|
IVW | 1.10 (1.02, 1.19) | 0.02 | 2.76/0.60 | 0.97 (0.87, 1.08) | 0.59 | 4.13/0.66 | 1.00 (0.96, 1.04) | 0.85 | 21.46/0.31 |
Weighted median | 1.08 (0.98, 1.20) | 0.13 | 0.99 (0.86, 1.14) | 0.89 | 0.98 (0.94, 1.03) | 0.44 | |||
MR-Egger | 0.97 (0.68, 1.39) | 0.89 | 2.27/0.52 | 1.05 (0.86, 1.27) | 0.66 | 3.28/0.66 | 0.98 (0.93, 1.03) | 0.41 | 20.00/0.33 |
MR-RAPS | 1.10 (1.01, 1.20) | 0.02 | 0.97 (0.86, 1.09) | 0.60 | 0.99 (0.95, 1.04) | 0.81 |
CI: confidence interval; OR: odds ratio; IVW: inverse-variance weighted; MR: Mendelian randomization; RAPS: robust adjusted profile score; SNP: single-nucleotide polymorphism
*Five/seven# SNPs were used as instrumental variables for periodontitis respectively
†Twenty SNPs were used as instrumental variables for Alzheimer’s disease