Table 1. Demographic and clinical variables of patients used in the validation cohort.
| Necrotizing fasciitis (n = 106) | Severe cellulitis (n = 825) | p-value | |
|---|---|---|---|
| Age a | 68 (58–78) | 68 (56–78) | 0.847 |
| Male b | 70 (66.0) | 509 (61.7) | 0.386 |
| Comorbidities b | |||
| Diabetes mellitus | 51 (48.1) | 362 (43.9) | 0.409 |
| Liver cirrhosis | 13 (12.3) | 99 (12.0) | 0.937 |
| Cancer | 12 (11.3) | 92 (11.2) | 0.958 |
| Peripheral vascular disease | 1 (0.9) | 63 (7.6) | 0.015 |
| Variables on admission b | |||
| Temperature > 38.0°C | 26 (24.5) | 114 (13.8) | 0.004 |
| Hypotensionc | 15 (14.2) | 14 (1.7) | < 0.001 |
| Pain | 100 (94.3) | 719 (87.2) | 0.032 |
| Hemorrhagic bullae | 14 (11.7) | 22 (2.7) | < 0.001 |
| LRINEC variables a | |||
| C-Reactive Protein, mg/L | 122.4 (44.4–206.8) | 31.4 (7.9–99.9) | < 0.001 |
| Total white cell count, per mm3 | 13.8 (10.1–18.0) | 9.7 (7.2–13.2) | < 0.001 |
| Hemoglobin, g/dL | 12.3 (11.0–13.5) | 12.2 (10.5–13.5) | 0.484 |
| Sodium, mmol/L | 135 (132–137) | 137 (133–139) | < 0.001 |
| Creatinine, μmol/L | 110.5 (75.8–160.9) | 87.5 (69.9–118.3) | 0.001 |
| Glucose, mmol/L | 8.9 (6.7–14.1) | 7.8 (6.4–10.8) | 0.019 |
| Mortality rate b | 9 (8.5) | 18 (2.2) | < 0.001 |
a The data given as median with interquartile range in parentheses
b The data given as the number of patients, with the percentage in parentheses
c Hypotension was defined as the systolic blood pressure less than 90 mmHg at ED triage