Table 2. NLRP3 and IL1B genotypes and IL2 Haplotype Frequency Distributions in patients with periodontitis and controls.

Nonsmokers and All Subjects were Analyzed Separately^*.

	Nonsmokers						All subjects
Polymorphisms/ Inheritance model	Periodontitis		Controls		OR (95%CI)	P value	Periodontitis		Controls		OR (95%CI)a	P value
Genotypes	n	%	n	%			n	%	n	%
NLRP3 rs4612666 T>C	N = 106		N = 150
Overdominant
T/T-C/C	48	44.0	94	62.7	Ref.
T/C	61	56.0	56	37.3	2.13 (1.29–3.53)	0.0029
IL1B -511C>T	N = 111		N = 138				N = 172		N = 171
Recessive
C/C-C/T	88	77.2	121	87.7	Ref.		131	76.2	147	86.0	Ref.
T/T	26	22.8	17	12.3	2.10 (1.08–4.11)	0.028	41	23.8	24	14.0	1.85 (1.05–3.26)	0.03
Haplotypeb	n	%	n	%			n	%	n	%
IL2 (+166, −330)c	N = 231		N = 231				N = 323		N = 323
GG-TT-TG	120	52.0	149	64.7	Ref.		176	54.3	207	64.3	Ref.
GT	111	48.0	82	35.3	1.68 (1.16–2.44)	0.0091d	147	45.7	116	35.7	1.49 (1.09–2.04)	0.02

OR: Odds Ratio, CI: Confidence Interval, N: total number, n: number of individuals, Ref.: the set of genotypes and haplotypes with higher frequency were used as reference group.

*Only significant results were shown.

^aAdjusted for smoking habits.

^b N: total of haplotypes, n: number of haplotypes in each group.

^cLinkage disequilibrium test of IL2 +166 and -330: D´ = 0.96, r² = 0.41.

^dNonsmokers: permutation P value = 0.029.