Table 1. Frequency of VHL mutations and VHL depletion of 3p in all renal cancers and in different histologic subtypes of renal cell carcinomas (RCC).

	VHL mutation analysis*				3p deletion analysis
	1–2 exons analyzed		3 exons analyzed
	n	mutated (%)	n	mutated (%)	n	deletion (%)
all cancers	705	63.7	431	40.6	1403	43.3
clear cell RCC	515	78.3	275	59.3	918	57.2
papillary RCC	68	19.1	58	5.2	210	17.6
oncocytoma	49	22.4	41	7.3	118	11.9
chromophobic RCC	38	18.4	32	3.1	79	17.7
clear cell (tubulo) papillary RCC	13	84.6	5	60.0	24	29.2
nephroblastoma	4	0.0	4	0.0	12	16.7
Xp11.2 translocated carcinoma	4	25.0	4	25.0	10	10.0
collecting duct carcinoma	0		0		3	0.0
metanephrogenic adenoma	0		0		3	33.3
tubular cystic RCC	1	0.0	1	0.0	2	0.0
multilocular cystic renal cell neoplasia of low malignant potential	2	50.0	2	50.0	2	50.0
acquired renal cystic disease associated RCC	1	0.0	1	0.0	1	0.0
cystic nephroma/mixed epithelial stromal tumor	1	0.0	1	0.0	1	0.0
medullary carcinoma	0		0		1	0.0
reninoma	0		0		1	100.0
n. o. s.	9	22.2	7	0.0	18	22.2

^*analyzing less than 3 exons introduces a bias no succesful analysis for mucinar tubular spindel cell carcinoma neuroendokrine carcinoma.