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. 2020 Jan 21;11(3):216–236. doi: 10.18632/oncotarget.27400

Figure 1. Effect of FBXW7 knockdown on cyclin E1 levels and prexasertib sensitivity.

Figure 1

Two triple-negative breast cancer tumor cell lines, MDA-MB-468 and MDA-MB-231, were exposed to siNT (non-target), siFBXW7, siBRCA1, or a combination of the two for 48 hours. (A) Effects on the siRNA target and CHK1 pathway-related proteins were assessed by western blot analysis. (B) Cell viability following prexasertib treatment of MDA-MB-468 or MDA-MB-231 cells exposed to NT or on-target siRNAs. Equal protein loaded in all lanes.