Table 1. Concentrations of memantine in pig plasma and selected organs/body fluids collected after a 7-day intragastric administration of 20 mg per day, with a 40 mg extra dose last day (administered 150 minutes after the last 20-mg dose on day 8).
| Tissue | Mean ± SEM (ng/mL or g) |
Tissue or body fluid/ plasma ratio |
|---|---|---|
| plasma | 5.08 ± 0.99 | 1.00 |
| stomach | 433.90 ± 160.61 | 85.41 |
| proximal jejunum | 3066.44 ± 715.63 | 603.63 |
| med jejunum | 2784.51 ± 925.09 | 548.13 |
| distal jejunum | 731.32 ± 445.02 | 143.96 |
| muscle | 33.99 ± 17.28 | 6.69 |
| fat | 23.37 ± 3.62 | 4.60 |
| spleen | 68.51 ± 13.96 | 13.49 |
| liver | 535.88 ± 138.03 | 105.49 |
| kidney | 41.96 ± 8.32 | 8.26 |
| heart | 28.93 ± 11.33 | 5.69 |
| lung | 444.73 ± 116.04 | 87.55 |
| medulla | 49.57 ± 19.53 | 9.76 |
| medulla oblongata | 22.90 ± 8.94 | 4.51 |
| hemisphere | 15.76 ± 6.56 | 3.10 |
| front lobe | 26.53 ± 7.62 | 5.22 |
| cerebellum | 14.76 ± 5.34 | 2.91 |
| pituitary gland | 100.40 ± 34.70 | 19.76 |
| hippocampus | 52.75 ± 16.74 | 10.38 |
| diencephalon | 26.30 ± 7.71 | 5.18 |
| urine | 75.46 ± 22.75 | 14.85 |
| bile | 40.27 ± 12.01 | 7.93 |