Skip to main content
. Author manuscript; available in PMC: 2021 Jan 16.
Published in final edited form as: Cell Chem Biol. 2019 Nov 14;27(1):57–65.e9. doi: 10.1016/j.chembiol.2019.10.013

Figure 1. Design and characterization of Wee1-targeted degraders.

Figure 1.

(A) Chemical structure of AZD1775, with linker attachment point highlighted in blue (B) Chemical structures of Wee1 degraders and the negative control, ZNL-02-178 (C) Histogram of the shortest pairwise distances between lenalidomide and AZD1775, with the red arrow corresponding to the docking pose in panel D (Rosetta) (D) Shortest pairwise distance docking pose between lenalidomide and AZD1775 (Rosetta)