Table 2. Changes in cryptococcal antigen titers and viable yeasts in the CSF of the 14 patients with cryptococcal meningitis.
| Case ID | CrAg titer | Culture | Outcome | ||||
|---|---|---|---|---|---|---|---|
| Day 1 | Day 15/29 | Day 30/59 | Day 60/79 | Day 90/120 | |||
| CRY017 | ≥1:1280 | pos day 1 | dead day 4 | ||||
| CRY033 | 1:20 | 1:10 | neg day 11 | dead day 69 | |||
| CRY041 | 1:640 | 1:320 | 1:320 | 1:160 | 1:40 | neg day 104 | dead day 141 |
| CRY061 | ≥1:1280 | pos day 1 | dead day 12 | ||||
| CRY067 | 1:320 | 1:640 | 1:40 | 1:40 | neg day 39 | dead day 68 | |
| CRY069 | ≥1:1280 | 1:1280 | 1:40 | 1:40 | neg day 28 | alive day 197 | |
| CRY070 | ≥1:1280 | ≥1:1280 | ≥1:1280 | ≥1:1280 | pos day 56 | dead day 73 | |
| CRY094 | ≥1:1280 | pos day 1 | dead day 19 | ||||
| CRY101 | ≥1:1280 | pos day 1 | dead day 4 | ||||
| CRY112 | 1:640 | 1:320 | 1:160 | 1:160 | neg day 122 | alive day 160 | |
| CRY114 | ≥1:1280 | pos day 1 | dead day 12 | ||||
| CRY124 | 1:320 | na | alive day 120 | ||||
| CRY128 | ≥1:1280 | 1:80 | 1:40 | 1:40 | 1:40 | neg day 77 | alive day 120 |
| CRY130 | 1:1280 | pos day 1 | lost to follow-up | ||||
na, not applicable (insufficient quantity)
Note: all patients were treated with fluconazole, except for patient CRY128, who received amphotericin B and high-dose fluconazole