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A) Six chondrosarcomas demonstrate TERT (NM_198253) and ATRX (NM_000489) mutations. B) Five cases are concurrent with IDH1 mutation while all cases are concurrent with CDKN2A/2B deletion or TP53 mutation. One case of ATRX missense mutation (p.D1925N) is wild-type for IDH1/IDH2. The co-occurrence of IDH1/IDH2 mutation with TERT/ATRX alterations is statistically significant (p=0.02).
