Table 1.
Select clinicopathologic characteristics. P value refers to the comparison between SLN and LND groups only.
| Characteristic | Whole Cohort | SLN | LND | HYST | P value for SLN vs LND only |
|---|---|---|---|---|---|
| N | 599 | 180 | 352 | 67 | |
| Age at surgery (years) | 0.37 | ||||
| Median | 61 | 61 | 61 | 61 | |
| Range | 27–85 | 34–85 | 27–83 | 31–85 | |
| BMI (kg/m2) | 0.99 | ||||
| Median | 29 | 29.1 | 29.0 | 33.0 | |
| Range | 17.9–68.6 | 17.9–67.6 | 18.2–59.1 | 19.5–68.6 | |
| FIGO stage | 0.01 | ||||
| I | 492 (82.3) | 159 (88.3) | 271 (77) | 62 (93.9) | |
| II | 15 (2.5) | 2 (1.1) | 12 (3.4) | 1 (1.5) | |
| III | 78 (13) | 18 (1.0) | 59 (16.8) | 1 (1.5) | |
| IV | 13 (2.2) | 1 (0.6) | 10 (2.8) | 2 (3) | |
| FIGO tumor grade | <0.001 | ||||
| 1 | 305 (51) | 122 (67.8) | 135 (38.4) | 48 (72.7) | |
| 2 | 132 (22.1) | 34 (18.9) | 88 (25) | 10 (15.2) | |
| 3 | 161 (26.9) | 24 (13.3) | 129 (36.6) | 8 (12.1) | |
| Histology | <0.001 | ||||
| Endometrioid | 472 (78.8) | 162 (90) | 256 (72.7) | 54 (80.6) | |
| Non-endometrioid | 60 (10) | 8 (4.4) | 47 (13.4) | 5 (7.5) | |
| Carcinosarcoma | 25 (4.2) | 2 (1.1) | 23 (6.5) | 0 (0) | |
| Sarcoma | 8 (1.3) | 1 (0.6) | 2 (0.6) | 5 (7.5) | |
| Other* | 34 (5.7) | 7 (3.9) | 24 (6.8) | 3 (4.5) | |
| Hypertension | 0.17 | ||||
| No | 281 (46.9) | 96 (53.3) | 165 (46.9) | 20 (29.9) | |
| Yes | 318 (53.1) | 84 (46.7) | 187 (53.1) | 47 (70.1) | |
| Diabetes | 0.01 | ||||
| No | 495 (82.6) | 161 (89.4) | 285 (81) | 49 (73.1) | |
| Yes | 104 (17.4) | 19 (10.6) | 67 (19) | 18 (26.9) | |
| CHF | 0.27 | ||||
| No | 592 (98.8) | 178 (98.9) | 351 (99.7) | 63 (94) | |
| Yes | 7 (1.2) | 2 (1.1) | 1 (0.3) | 4 (6) | |
| Renal disease | 1.0 | ||||
| No | 588 (98.2) | 178 (98.9) | 347 (98.6) | 63 (94) | |
| Yes | 11 (1.8) | 2 (1.1) | 5 (1.4) | 4 (6) | |
| EBRT | 0.1 | ||||
| No | 550 (91.8) | 170 (94.4) | 317 (90.1) | 63 (94) | |
| Yes | 49 (8.2) | 10 (5.6) | 35 (9.9) | 4 (6) | |
| Total LNs removed | <0.001 | ||||
| Median | 11 | 4 | 19 | 0 | |
| Range | 0–80 | 1–21 | 1–80 | 0–1 |
Values are N(%) except where noted otherwise
SLN=sentinel lymph node mapping cohort; LND=lymphadenectomy cohort; HYST=hysterectomy alone cohort BMI=body mass index; FIGO=International Federation of Gynecology and Obstetrics; CHF=congestive heart failure; EBRT=external beam radiotherapy (postoperative); LN=lymph nodes
*
other histology includes: adenocarcinoma NOS, carcinoma NOS, atypical hyperplasia, mixed histologies, squamous cell carcinoma, undifferentiated carcinoma, yolk sac tumor