Table 4.
EORTC QLQ-C30 and -EN24 scores between patients with and without patient-reported lower-extremity lymphedema
| No patient-reported LEL | Patient-reported LEL | P value† | |
|---|---|---|---|
| EORTC QLQ-C30 | |||
| Overall Score | |||
| QLQ Total Score | 94.9/91.8 (27.6–100) | 84.7/79 (19.6–100) | <0.001 |
| Global QOL | 83.3/83.6 (0–100) | 66.7/66.8 (0–100) | <0.001 |
| Functional Scales | |||
| Physical functioning | 100/90.4 (0–100) | 86.7/75.8 (0–100) | <0.001 |
| Role functioning | 100/95 (0–100) | 83.3/80 (0–100) | <0.001 |
| Emotional functioning | 91.7/86.3 (0–100) | 75/73.2 (0–100) | <0.001 |
| Cognitive functioning | 100/89.4 (16.7–100) | 83.3/77.4 (0–100) | <0.001 |
| Social functioning | 100/93.8 (0–100) | 83.3/77.3 (0–100) | <0.001 |
| Symptom Scales | |||
| Fatigue | 0/12.9 (0–100) | 22.3/31.7 (0–100) | <0.001 |
| Nausea and vomiting | 0/2.3 (0–100) | 0/7.3 (0–100) | <0.001 |
| Pain | 0/7.7 (0–100) | 16.7/28.5 (0–100) | <0.001 |
| Dyspnea | 0/6.4 (0–100) | 0/17.5 (0–100) | <0.001 |
| Insomnia | 0/16.1 (0–100) | 33.3/31.1 (0–100) | <0.001 |
| Appetite loss | 0/3.3 (0–100) | 0/9.9 (0–100) | <0.001 |
| Constipation | 0/7.8 (0–100) | 0/17.8 (0–100) | <0.001 |
| Diarrhea | 0/5.4 (0–100) | 0/15.9 (0–100) | <0.001 |
| Financial difficulties | 0/5 (0–100) | 0/19.5 (0–100) | <0.001 |
| EORTC QLQ-EN24 | |||
| Functional Scales | |||
| Sexual interest* | 33.3/23.3 (0–100) | 0/19.5 (0–100) | 0.035 |
| Sexual activity** | 0/19.5 (0–100) | 0/12.7 (0–100) | 0.01 |
| Sexual enjoyment*** | 33.3/49.2 (0–100) | 33.3/33.3 (0–100) | <0.001 |
| Symptom Scales | |||
| Lymphedema | 0/3 (0–100) | 33.3/38.3 (0–100) | <0.001 |
| Urologic symptoms | 8.3/15.1 (0–75) | 25/29.9 (0–100) | <0.001 |
| Gastrointestinal symptoms | 6.7/7.8 (0–100) | 13.3/20.7 (0–86.7) | <0.001 |
| Poor body image | 0/9.1 (0–100) | 16.7/25.6 (0–100) | <0.001 |
| Sexual/vaginal problems**** | 22.2/35.3 (0–100) | 44.4/48.5 (0–100) | 0.019 |
| Pain in back and pelvis | 0/14.4 (0–100) | 33.3/36.4 (0–100) | <0.001 |
| Tingling/numbness | 0/17.8 (0–100) | 33.3/38.6 (0–100) | <0.001 |
| Muscular pain | 0/21.4 (0–100) | 33.3/43.2 (0–100) | <0.001 |
| Hair loss | 0/12.4 (0–100) | 0/25 (0–100) | <0.001 |
| Taste change | 0/4.4 (0–100) | 0/10.1 (0–100) | <0.011 |
LEL=lower-extremity lymphedema; QOL=quality of life
Data are reported as Median/Mean (range)
†
P-value obtained using Wilcoxon Rank Sum Test and all except “sexual interest” and “sexual activity” remain significant using Bonferroni correction for multiple comparisons adjustment
*
Data missing from 56
**
Data missing from 62
***
Data missing from 321
****
Data missing from 317