Tg4510 mice vaccinated with AV-1980R/A display decreased levels of phosphorylated tau and total tau in the posterior cortex soluble fraction when compared to AdvaxCpG adjuvant treated mice when analyzed by ELISA.
Level of total (A) and several phosphorylated tau (pSer396 (B), pSer199 (C), pT181(D), pT231(E), in brain soluble extractions of posterior cortex from Tg4510 mice treated with AdvaxCpG adjuvant or AV-1980R/A, were analyzed by ELISA. Error bars represent average ± SEM (n = 11–12) Statistical significance was calculated against AdvaxCpG group using unpaired t-test. **p < 0.01.