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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Neurobiol Dis. 2019 Oct 17;134:104636. doi: 10.1016/j.nbd.2019.104636

Fig. 3.

Fig. 3.

AV-1980R/A induced strong cellular response specific to Th epitopes incorporated in the MultiTEP platform without activating potentially harmful auto-reactive Th cells specific to tau. Splenocytes from individual mice were re-stimulated in vitro with a cocktail of 12T-helper epitope peptides (2 μg/ml each) and several individual peptides [PADRE, P23, P30, P17, P28] incorporated in MultiTEP platform, as well as Tau2–18 peptide (10 μg/ml). IFNγ spot-forming colonies (SFC) were detected by ELISPOT assay and error bars indicate mean ± SEM (n = 11 per group).